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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T72408 | PI3K/mTOR Inhibitor-5 | ||
PI3K/mTOR Inhibitor-5 is a potent dual inhibitor of PI3K and mTOR, displaying IC50 values of 86.9 nM (for PI3K) and 14.6 nM (for mTOR), respectively. | |||
T2265 | Bimiralisib | 5-(4,6-dimorpholino-1,3,5-triazin-2-yl)-4-(trifluoromethyl)pyridin-2-amine,PQR309,PI3K-IN-2 | Others , PI3K , S6 Kinase , mTOR |
Bimiralisib (PI3K-IN-2) is an orally bioavailable pan inhibitor of PI3K and inhibitor of the mTOR, with potential antineoplastic activity. PI3K-IN-2 inhibits the PI3K kinase isoforms alpha, beta, gamma and delta and, to ... | |||
T0365 | Thioridazine hydrochloride | Mellaril,Aldazine | Apoptosis , Potassium Channel , Dopamine Receptor , 5-HT Receptor , Antibacterial , Adrenergic Receptor , Autophagy |
Thioridazine hydrochloride (Mellaril) , an antipsychotic drug, is used in the therapy of psychosis and schizophrenia and shows serotonin antagonism or D4 selectivity. | |||
T2235 | Dactolisib | BEZ235,NVP-BEZ235 | ATM/ATR , PI3K , mTOR , Autophagy |
Dactolisib (BEZ235) is an orally bioavailable inhibitor of PI3K and mTOR (IC50s: 4 nM/5 nM/7 nM/75 nM, and 20.7 nM for p110α/p110γ/p110δ/p110β and mTOR). | |||
T14552 | Dactolisib Tosylate | BEZ235 Tosylate,NVP-BEZ 235 Tosylate | PI3K , mTOR |
Dactolisib Tosylate (BEZ235 Tosylate) is a dual kinase inhibitor that targets PI3K and mTOR. dactolisib Tosylate exhibits IC50 values of 4, 75, 7, and 5 nM for PI3Kα, β, γ, and δ, respectively. dactolisib Tosylate inhibi... | |||
T1916 | Apitolisib | RG 7422,GNE 390,GDC-0980 | Apoptosis , PI3K , mTOR |
Apitolisib (RG 7422), an effective, class I PI3K inhibitor for PI3Kα(IC50=5 nM), PI3Kβ(IC50=27 nM), PI3Kδ(IC50=7 nM), PI3Kγ (IC50=14 nM), is used in trials study of solid cancers, breast cancer, prostate cancer, renal ce... | |||
T36084 | PKI-179 | ||
PKI-179 is a potent, orally active compound that functions as a dual PI3K/mTOR inhibitor. It demonstrates IC50 values of 8 nM for PI3K-α, 24 nM for PI3K-β, 74 nM for PI3K-γ, 77 nM for PI3K-δ, and 0.42 nM for mTOR. Additi... |